Median overall survival was not different over time (9.2 versus 12.5 months p = 0.937).
In the second time period, there were less irresectable tumors (17.7% versus 5.8% p = 0.044). Reasons for cancelation were disease progression (50 patients, 43.9%), poor general condition (26 patients, 22.8%), irresectability (14 patients, 12.3%), patients’ own decision (15 patients, 13.2%), and death during neoadjuvant treatment (9 patients, 7.9%). In 114 of 679 patients (16.8%), surgery was not performed after neoadjuvant treatment. Subanalysis was performed according to time period (2002–2010 versus 2011–2015) and histology (adenocarcinoma versus squamous cell carcinoma). We retrospectively analyzed patients treated between 20 for locally advanced esophageal cancer, who did not undergo esophagectomy after neoadjuvant treatment. The purpose of our study was to investigate the group of patients, scheduled for neoadjuvant treatment followed by esophagectomy, who never made it to esophageal resection. However, not all patients who started neoadjuvant treatment will undergo esophageal resection. ** Includes FREE ‘Benjamin’s Flight’ level pack, giving you more story and 20 additional levels to play through with young Benjamin, who goes in search of the Fountain of Wisdom aided by his father's incredible invention.Neoadjuvant treatment followed by esophagectomy is standard practice in locally advanced esophageal cancer. ** Award winning story narrated by Danny Wallace
** A minimalist game about friendship and jumping
** Experience the BAFTA winning, million selling game from creator Mike Bithell, now an Universal app available for iPad (iPad 2 minimum), iPhone (iPhone 4 minimum, iPhone 4S & newer recommended) and iPod Touch (iPod Touch 5 minimum)! "Thomas Was Alone is a winning piece of minimalist game design that manages to do a lot with a little in an industry which far too frequently achieves the exact opposite, and it deserves much praise for that." “It proves that you don't need tens of millions of dollars and hundreds of staff to make a game story worth telling, just a good hook, an engaging vision, and a whole lot of heart.” "Sumptuous visuals and an engaging story." “Across the game’s gaps and hazards, there’s a real emotional journey filled with narcissism and jealousy.” BAFTA 2013 Winner: Performance (Danny Wallace as Narrator) Experience 100 levels of award-winning platform gameplay and take part in an emotional story narrated by Danny Wallace. Meet Thomas, a curious rectangle, and help him unravel the mysteries of his existence in a wonderfully strange world.
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